By J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)
Biologists and radiotherapists current their experimental paintings and medical facts within the box of radiation accidents of standard tissues and organs. specific regard is payed to the relevance of organic mechanisms in medical occasions. ideas of radiation harm and mixed therapy toxicity in radio-chemotherapy are being defined. the most subject matters mentioned are the significance of microvasculature, time, doseand fractionation and elements editing scientific radioresponse for early andlate radiation results. Tissues and organs thought of during this quantity are mucosa and pores and skin, lung and middle, bladder and muscle, CNS and eye. specific difficulties of pediatric radiotherapy, TBI, IORT and moment malignacies also are mentioned.
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Extra resources for Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance
2 compared with about 70 Gy in Fig. 1. The reason for this difference between these two studies is not yet understood. C. Joiner et al. 120 - LQ Kidney . . . 100 >~ CD 80 en o "0 * .... 1 (Gy) Fig. 3. , 6). Irradiation was with 10 (open symbols) or 30 (filled symbols) X-ray fractions followed by a neutron top-up treatment, and is compared with the response to a full course of X-ray fractions (no top-up). 8 Gy; however, the induced repair model (continuous line; dotted lines, 95% confidence limits) fits all the data well.
Radiat OncoI16:129-137 Hopewell JW (1983) Radiation effects on vascular tissue. In: Potten CS, Hendry JH (eds) Cytotoxic insult to tissue: effects on cell lineages. Churchill Livingstone, Edinburgh, pp 228-257 Hopewell JW, Wiernik G (1977) Tolerance of the pig kidney to fractionated Xirradiation. In: IAEA (eds) Radiobiological research and radiotherapy. IAEA, Vienna, pp 65-73 Jen YM, Hendry JH (1993) Dose-fractionation sensitivity of mouse kidney clonogens measured using different interfraction intervals and postirradiation assay times.
Errors are SEM, within the data points if not shown. Continuous line, fit of the induced repair model; dotted lines, 95% confidence limits on mean (expected) values of the fit This equation is shown in Fig. 1 as a continuous/dashed line (labelled LQ). 6 Gy the data fit the LQ model very well, but below this dose there is a significantly reduced total dose compared with the LQ prediction: the LQ model underestimates the true effect of these low doses per fraction. 07Gy, plus a single neutron top-up.
Acute and Long-Term Side-Effects of Radiotherapy: Biological Basis and Clinical Relevance by J. W. Hopewell, W. Calvo, R. Jaenke, H. S. Reinhold, M. E. C. Robbins, E. M. Whitehouse (auth.), PD Dr. Wolfgang Hinkelbein, Dr. Gregor Bruggmoser, Prof. Dr. Hermann Frommhold, Prof. Dr. Michael Wannenmacher (eds.)