Download e-book for kindle: Alcohol and abnormal protein biosynthesis; biochemical and by Marcus Adolphus Rothschild; Murray Oratz; Sidney S Schreiber

By Marcus Adolphus Rothschild; Murray Oratz; Sidney S Schreiber

ISBN-10: 0080177085

ISBN-13: 9780080177083

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Protein Synthesis Consists of Three Phases B. Role of tRNA Charging C. Role of Cell Sap Factors V. Amino Acid Supply and RNA Metabolism VI. Summary and Perspective References 33 34 34 39 39 42 42 45 45 47 48 51 58 60 I. INTRODUCTION One billion years ago, the first animal cells emerged as a result of expelling from their genome the biosynthetic pathways for vitamins and for half of the common amino acids, which thus became the essential amino acids of animal nutrition [ 1 ] . Ever since that event, animal life has evolved around the need for food, o f which the requirement for amino acids is a major component.

Similarly, Clemens [79, 80] reports that, when slices of rat liver are incubated with high concentrations of amino acids, cell sap prepared from the slices stimulates incorporation of free amino acids and also of amino acids bound to tRNA into proteins in a cell-free system. This suggests that amino acid administration does not act by increasing the levels of the amino acid activating enzymes but through the transfer of amino acids from tRNA to ribosomes, a conclusion that is supported by the observation [81] that the activity of liver activating enzymes is not altered by a few days of fasting.

Measurement of synthesis rates of liver-produced plasma proteins, Biochem. , 89, 277 ( 1 963). 3. Rothschild, M. , and Schreiber, S. S. Amino-acid regulation of albumin synthesis, I. , 98, 395 ( 1969). In Vitro Analysis of Hepatic Plasma Protein Synthesis 29 4. Liver: Mechanisms of Function and Malfunction. (Ed. F. F. Becker), Marcel Dekker, New York. In press ( 1974). 5. Becker, F. F. Structural and functional correlation in the dividing hepatocyte, in Control of Cell Division, (Ed. R. , 1 969, p.

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Alcohol and abnormal protein biosynthesis; biochemical and clinical by Marcus Adolphus Rothschild; Murray Oratz; Sidney S Schreiber

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